Title:

Medical Director, Immunology ProgramsType:

OnsiteAbout Sail:

Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail’s platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.The Role:

We are seeking an experienced Medical Director to lead our Immunology Programs towards clinical testing. The successful candidate will provide medical expertise and strategic direction for our immunology pipeline, from drug candidate nomination through IND and clinical development. This key leadership role will collaborate across multiple functions, including research, biomarker, regulatory, TDO, and business development to advance our existing and growing immunology pipeline of RNA-based in vivo reprogramming drug candidates towards clinical testing. This is an onsite position, with in-office expectations tailored to the specific needs of the team, ensuring responsibilities align with the team''s requirements.Responsibilities:

Provide medical and scientific leadership for immunology clinical development programsDevelop and implement clinical development strategies and study protocolsCollaborate with research teams to facilitate translation of preclinical concepts into clinical applications, definition of TPP/MPP, CDP, indication selection, and assessment of the competitive therapeutic landscapeAuthor clinical sections of regulatory documents (INDs, CTAs, BLAs, etc.); serve as medical monitor for clinical trials, ensuring patient safety and data integrity; analyze and interpret clinical data to guide program decision-makingRepresent the company at scientific meetings and engage with key opinion leadersContribute to publications and presentations of clinical research findingsPartner with business development on strategic opportunities, partnership discussions, and external collaborationsQualifications:

MD or MD/PhD with board certification in immunology, rheumatology, allergy, or relevant specialtyMinimum 5-7 years of industry experience in clinical development within immunology or related therapeutic areas, with strong knowledge of immune-mediated diseases across autoimmune and immuno-oncology, and current treatment landscapesDemonstrated track record of successful contribution to immunotherapy development programs; experience with clinical development of CAR cell therapy products and/or RNA-LNP products strongly preferred, but not requiredStrong understanding of regulatory requirements for drug developmentExperience in Medical MonitoringExcellent knowledge of translational immunology and biomarker developmentExperience with regulatory submissions and interactions with health authoritiesExperience as a medical monitor for clinical trials and familiarity with GXP guidelinesStrong scientific publication record and presentation skillsOutstanding communication skills and ability to translate complex scientific conceptsProven ability to work effectively in cross-functional teamsPreferred Qualifications:

Experience with both early and late-stage clinical development programsBackground in designing innovative clinical trialsExperience with various immunotherapeutic modalities and especially RNA, antibodies, and/or cell therapies is preferredUnderstanding of precision medicine approaches in immunologySail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.Apply for this job

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