CK Group are recruiting for an experienced and dynamic Scientist, at either Senior/ Principal level, to join an early-stage biotechnology start-up, based in Oxford, on a permanent basis.The Company:Our client is an early-stage biotechnology start up, combining artificial intelligence (AI), and advanced high-throughput TCR screening techniques to revolutionise the treatment of solid cancers.Location: Oxford.The Role:To lead the in vivo and in vitro validation of T-cell engagers, and help drive forward the development of TCR engineering and processes.Responsibilities:To perform high-throughput TCR display methods by purifying recombinant TCRs.Carry out protein characterisation (expression, purification and biophysical analysis).Design and characterise TCRs for disease targets.Oversee lab protocols and technical documents.To be hands-on in the lab and manage tissue culture preparations.Skills in data analysis (using software R) for Next Gen Sequencing analysis - desirable. Your Background:PhD qualified (biochemistry, immunology, cell biology) plus strong laboratory experience (academia and industry).Experience in in vivo and in vitro validation of T-cell engagers (TCEs).Experience in Investigational New Drug (IND-enabling/ approval) - ESSENTIAL.Expertise in cell and immunological assays (flow cytometry, ELISA) with knowledge around cloning and PCR.Strong background in protein characterisation and biophysical characterisation. Benefits: Competitive salary, option for home work